Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation
نویسندگان
چکیده
منابع مشابه
Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells.
Arterial calcification is a phenotype of vascular repair in atherosclerosis, diabetes, hyperphosphatemic renal failure, and aging. Arterial calcification is modulated by transition of arterial smooth muscle cells (SMCs) from contractile to chondro-osseous differentiation programmed in response to increases in P(i), bone morphogenetic protein-2, and certain other stimuli. Transglutaminase (TG)2 ...
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In osteoarthritis (OA), low-grade joint inflammation promotes altered chondrocyte differentiation and cartilage catabolism. S100/calgranulins share conserved calcium-binding EF-hand domains, associate noncovalently as homodimers and heterodimers, and are secreted and bind receptor for advanced glycation end products (RAGE). Chondrocyte RAGE expression and S100A11 release are stimulated by IL-1b...
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2011
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-011-1010-3